Características histológicas de bolhas filtrantes de pacientes submetidos à trabeculectomia com uso de 5-FU no intra-operatório

Características histológicas de bolhas filtrantes de pacientes submetidos à trabeculectomia com uso de 5-FU no intra-operatório


José Garone Gonçalves Lopes Filho,
Remo Susanna Jr.,
Ruth Miyuki Santo


Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749versão On-line ISSN 1678-2925

Arq. Bras. Oftalmol. vol.61 no.1 São Paulo fev. 1998


Authors studied the histological aspects of filtering blebs conjunctiva of two patients who had undergone surgical revision of the filtration site after trabeculectomy with 5-Fluorouracil during the procedure. Blebs were excised due to ocular hypotony. Light microscopy showed: conjunctival epithelium attenuation, substantia propria with loosely organized collagen, few blood vessels and rare inflammatory cells. Our histhopathological findings are similar to those reports in the literature for cases treated with mitomycin-C.

Key words: 5-Fluorouracil; Trabeculectomy; Ocular hypotony; Pathologic anatomy; Histology


1 Kitazawa Y, et al. Trabeculectomy with mitomycin. A comparative study with fluorouracil. Arch Ophthaimol 1991;109:1693.
2 Chen CW. Enhanced intra-ocular pressure controlling effectiveness of trabeculectomy by local application of mitomycin C. Trans. Asia-Pacific Acad Ophthalmol 1983;9:172.
3 Palmer SS. Mitomycin as adjunctive chemotherapy with trabeculectomy. Ophthalmology 1991; 98:317.
4 Skuta GL et al. Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery. Ophthalmology 1992;99:438.
5 Smith MF, et al. - Results of intraoperative 5-fluorouracil supplementation on trabeculectomy for open-angle glaucoma. Am J Ophthalmol 1992;114:737.
6 Jampel HD, et al. Hypotony maculopathy following trabeculectomy with mitomycin C Arch Ophthalmol 1992;110:1049.
7 Kirchhof BE, Diestelhorst M. The effect of mitomycin C on the aqueous humor dynamics in glaucomatous eyes. ARVO abstracts. Supplement to Invest Ophthalmol Vis Sei Philadelphia: J. B. Lippincott, 1993, p. 815.
8 Fankhouser F. Wound healing in glaucoma filtering surgery. New York: Kugler, 1992.
9 Falk FY, et al. Mitomycin versus 5-fluorouracil antimetabolite therapy for glaucoma filtration surgery. Semin Ophthalmol 1992;7:97.
10 Parrish RK. Who should receive antimetabolite after filtering surgery?. Arch Ophthalmol 1992;110:1069-71.
11 Skuta GL, et al. Intraoperative mitomycin versus postoperative 5-fluorouracil in high risk glaucoma filtering surgery. Ophthalmology 1992;99:438-44.
12 Moster MR, et al. Complications of topical intraoperative subconjunctival mitomycin C in glaucoma filtration surgery. Invest Ophthalmol Vis Sci 1993; 34(supp):730.
13 Gass, JDM. Hypotony Maculopathy. In: Bellows JG, ed. Contemporary Ophthalmology: Honoring Sir Stewart Duke Elder. Baltimore, Md: Williams & Wilkins; 1972;343-66.
14 Liebman JM. et al. Management of chronic hypotony after glaucoma filtration surgery. J Glaucoma 1996;5:210-20.
15 Hutchinson AK. et al. Clinicopathologic features of excised mitomycin filtering blebs. Arch Ophthalmol 1994;112:74-9.
16 Nuyts, RMMA. et al. Histopathologic effects of mitomycin C after trabeculectomy in human glaucomatous eyes with persistent hypotony. Am J Ophthal 1994;118:225-37.
17 Shields, MB. et al. Clinical and histopathologic observations concerning hypotony after trabeculectomy with adjunctive mitomycin C Am J Ophthal 1993;116:673-83.