Efeitos da nimodipina na circulação retrobulbar em glaucoma de pressão normal: análise por Doppler colorido

Efeitos da nimodipina na circulação retrobulbar em glaucoma de pressão normal: análise por Doppler colorido

Autores:

Wilma Lelis Barboza,
Vital Paulino Costa,
Lazio Molnar,
Giovani Guido Cerri

ARTIGO ORIGINAL

Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749versão On-line ISSN 1678-2925

Arq. Bras. Oftalmol. vol.60 no.2 São Paulo abr. 1997

http://dx.doi.org/10.5935/0004-2749.19970080

SUMMARY

Colar Doppler imaging (CDI) was employed to investigate the effects of nimodipine on the retrobulbar circulation of twelve patients with normal tension glaucoma. In a crossed, double masked, placebo controlled study, we measured the peak systolic and end diastolic velocities and the vascular resistance index of the ophthalmic, central retinal and short posterior ciliary arteries. Our results suggest that nimodipine does not improve the hemodynamic parameters in normal tension glaucoma patients by CDI analysis.

Key words: Colar Doppler; Normal tension glaucoma; Nimodipine

REFERÊNCIAS

1 GASSER, P.; FLAMMER, J.; GUTHAUSER, U.; MAHLER, F. - Do vasospasm provoke ocular diseases? Angiology, 41(3): 213-220, 1990.
2 GOODMAN AND GILMAN'S - The calcium channel blockers. In: The Pharmacological Basis of Therapeutics 1. Mc GRAW-HILL I. E., 1992, pp 774-778.
3 COSTA, V. P. - O uso do Calor Doppler em Oftalmologia. Arq. Bras. de Oftalmol. 57(3): 150-153, 1994.
4 COSTA, V. P.; SUZUKI, R.; MOLNAR, L.; CERRI, G. G. - A reprodutibilidade do exame de Doppler colorido. Rev. Bras. de Oftalm., 55: 43-47, 1996
5 LIEB, W. E.; FLAHARTY, P. M.; SERGOTT, R. C. et al - Colar Doppler imaging provides accurate assessment of orbital blood flow in occlusive carotid artery disease. Ophthalm. 98: 548-552, 1991.
6 SERGOTT, R. C.; FLAHARTY, P. M.; LIEB, W. E., et al - Colar Doppler imaging identifies four syndromes of the retrobulbar circulation in patients with amaurosis fugax and central retina! artery occlusions. Trans. Am. Ophthalmol. Soc., 90: 383-398, 1992.
7 KITAZAWA, Y.; SHIRAI, H.; GO, F. J. - The effect of calcium antagonist on visual field in low tension glaucoma. Graefes Arch. Clin. Exp. Ophthalm. 227: 408, 1989.
8 NETLAND, P. A.; CHATURVEDI, N.; DREYER, E. 8. - Calcium channel blockers in management of low tension and open angle glaucoma. Am. J. Ophthalm. 115: 608 -613, 1993.
9 PILTZ, J. R.; BOSE, S.; GRUNWALD, J. E.; PETRIG, B. L.; RIVA, C. E. - Effect of nimodipine on automated threshold perimetry, spatial contrast sensitivity and macular blood flow in normal tension glaucoma and controls. Invest. Ophthalm. Vis. Sci. 34: 2881, 1993.
10 HARRIS, A.; SERGOTT, R. C.; SPAETH, G. L.; KATZ, J. L.; SHOEMAKER, B. A.; MARTIN, B. J. - Calor Doppler analysis of ocular blood velocity in normal tension glaucoma. Am. J. Ophthalm. 118: 642-649, 1994.
11 NEUDORFER, M.; ALMOG, Y.; KESSLER, A.; LAZAR, M.; GEYER, O. - Calcium channel blockers do not alter ocular blood tlow in normal tension glaucoma. Invest. Ophth. Vis. Sci. 37: S271, 1996.
12 EVANS, D. W.; HARRIS, A.; CANTOR, L. B.; WILSON, R.; MASTER, B. J. - Changes in retrobulbar hemodynamics and visual function in low tension glaucoma patients after six months of treatment with nifedipine. IVOS 37: S 271, 1996.
13 CHRIST, A.; PILLUNOT, L. E.; KUBA, G. B.; BAUNERT, S.; LANG, G. K. - Contrast sensiti vity and optic nerve blood tlow after applications of calcium channel blockers. IVOS 37: S271, 1996.
Política de Privacidade. © Copyright, Todos os direitos reservados.