Eficácia da ciprofloxacina e da tetraciclina no tratamento do tracoma: Estudo clínico e microbiológico

Eficácia da ciprofloxacina e da tetraciclina no tratamento do tracoma: Estudo clínico e microbiológico


Consuelo Bueno Diniz Adan,
Marinho Jorge Scarpi,
Tânia Guidugli


Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749versão On-line ISSN 1678-2925

Arq. Bras. Oftalmol. vol.59 no.6 São Paulo dez. 1996


Three hundred and ninety-six inhabitants of Sítio Barro Vermelho, located at Barbalha city, Ceará, Brazil, were studied, prospectivelly, in a transversal cut, regarding their ocular clinical and laboratorial features. The purpose of the study was to evaluate the trachoma's prevalence and the clinical and antimicrobial efficacy of cloridrate of ciprofloxacin (0.3%) drops and tetracycline 1% ointment in trachoma's treatment.

It was found that trachoma, in its different forms, occurs in 38.13% of the population. The follicular form occurred more often in children and the cicatricial one in adults. In this population, trachoma was not a blindness disease.

The treatment was followed significantly by the patients but not the way it had been originally proposed. This was due to cases of mild manifestation of the disease, side-effects of the ointment and low social, economical and cultural level of the patients in generally.

Regarding the clinical response, there was no significant difference between the two different forms of treatment and the placebo.

The treatment of sample reduced the number of microorganisms at the conjunctive. This reduction of microorganisms was noted independently of the type of treatment, including the placebo, but it did not happen in those persons who refused treatment altogether. Therefore, the simple ocular hygiene changes the behavior of trachoma. The improvement of the social, economic and educational conditions of the population would be the safer way to eradicate the trachoma from our country.


1 DAWSON, C. R.; JONES, D.; TARIZZO, M. L. - Guide to trachoma control in programs for the prevention of blindness. Public World Health Organ., Genéve, ed. Macmillan/Kundig/Vitesse, 1981a, pp 7-55.
2 THYLEFORS, B. - Development of Trachoma Control Programs and the Involvement of National Resources. Rev. Infect. Dis., 7: 774-6, 1985.
3 JONES, B. R. - The prevention of blindness form trachoma. Trans. Ophthalmol. Soc. K., 95: 16-33, 1975.
4 FOULKES, S. J.; DEIGHTON, R.; FEENEY, A. R. B.; MOHANTY, K. C.; FREEMAN, C. W. J. - Comparison of direct immunofluorescence and cell culture for detecting Chlamydia trachomatis. Genitourin. Med., 61: 255-7, 1985.
5 WILSON, M. C.; VELASCO, F. M.; TIELSCH; J. M.; TAYLOR, H. R. - Direct-Smear Fluorescent Antibody cytology as à field diagnostic tool for trachoma. Arch. Ophthalmol., 104: 688-93, 1986.
6 BOWIE, W. R. - Epidemiology and therapy of Chlamydia trachomatis infections. Drugs., 27: 459-68, 1984.
7 NEU, H. C. - Microbiologic aspects of fluoroquinolones. Am. J. Ophthalmol., 112: 155-245, 1991.
8 THYLEFORS, B.; DAWSON, C. R.; JONES, B. R.; WEST, S.; TAYLOR, H. R. - A simple system for the assessment of trachoma and its complications. Bull. WHO, 65: 477-83, 1987.
9 TAYLOR, H. R.; RAPOZA, P. A.; WEST, S.; JOHNSON, S.; MUNOZ, B.; KATALA, S.; MMBAGA, B. B. O. - The epidemiology of infection in trachoma. Invest. Ophthalmol. Vis. Sci., 30: 1823-33, 1989a.
10 SCARPI, M. J. - Aspectos do tracoma em três povoados do Estado da Bahia. Tese apresentada ao Curso de Pós-Graduação da Escola Paulista de Medicina, para obtenção do Título de Doutor em Medicina, São Paulo, 1989.
11 SCARPI, M. J.; PLUT, R. C. A.; OLIVEIRA, H. A. - Prevalência do tracoma no povoado de Mocambo, Estado do Ceará, Brasil. Arq. Bras. Oftalmol., 52: 177-9, 1989.
12 JAWETZ, E; HANNA, L.; DAWSON, C.; WOOD, R.; BRIONES, O. - Subclinical infections with tric agents. Am. J. Ophthalmol., 63: 1413-7, 1967.
13 NOBREGA, M. J.; BONOMO, P. P.; SCARPI, M. J.; GUIDUGLI, T.; CAMPOS, C. E. G; JULIANO, Y.; NOVO, N. F. - Prevalência do tracoma em, crianças pré-escolares e escolares da periferia da cidade de Joinville, Estado de Santa Catarina, Brasil. Arq. Bras. Oftalmol., 56: 13-7, 1993.
14 TAYLOR, H. R.; WEST, S.; MMBAGA, B. B. O.; KATALA, S.; TURNER, V.; LYNCH, M.; MUNOZ, B.; RAPOZA, P. A. - Hygiene factors and increased risk of trachoma in Central Tanzania. Arch. Ophthalmol., 107: 1821 -5, 1989b.
15 MONNICKENDAM, M. A. & PEARCE, J. H. - Imune response and chlamydial infections. Br. Med. Bull., 39: 187-93, 1983.
16 MABEY, D. C. W.; DOWNES, R. M.; DOWNES, B.; BAILEY, R. L.; DUNN, D. T. - The impact of medical services on trachoma in a Gambian village: antibiotics alone are not the answer. Ann. Trop. Paediatrics., 11: 295-300, 1991.
17 WEST, S.; RAPOZA, P.; MUNOZ, B.; KATALA, S.; TAYLOR, H. R. - Epidemiology of ocular chlamydial infection in a trachomahyperendemic area. J. Infect. Dis., 163: 752-6, 1991.