Estudo da toxicidade corneana de dois perfluorocarbonos líquidos

Estudo da toxicidade corneana de dois perfluorocarbonos líquidos


Joaquim M. de Queiroz Jr.,
Hamilton Moreira,
Peter E. Liggett,
Peter J. McDonnell,
Serdar A. Özler


Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749versão On-line ISSN 1678-2925

Arq. Bras. Oftalmol. vol.55 no.6 São Paulo nov./dez. 1992


Corneal toxicity of perfluoropolyether and perfluoroctane was evaluated by uniocular injection of each of these substances into the anterior chamber of eight rabbits. Corneal clinical appearance was studied at one and two weeks following injection, after which the animals were sacrificed and the corneas processed for light and for scanning electron microscopy. Animals injected with perfluoropolyether showed more intense inflammatory reaction and corneal vascularization (P<0.02) Than did those receiving perfluoroctane. However, the perfluoroctane group showed more of the “fish-egging” phenomenon (P<0.03). Light and scanning electron microscopy disclosed endothelium cell loss in both perfluorocarbon liquid groups. These results suggest that corneal toxicity of these two perfluorocarbon liquids is a major problem after the first week in the anterior chamber.


1 CHANG S. - Low viscosity liquid flurochemicals in vitreous surgery. Am. J. Ophthalmol. 1987; 103: 38-43.
2 CHANG S., LINCOFF H., ZIMMERMAN N.J., FUCHUS W. - Giant retinal tears: surgical techniques and results using perfluorocarbon liquids. Arch Ophthalmol. 1989; 107: 761-766.
3 CHANG S., OZMERT E., ZIMMERMAN N.J. - Intraoperative perfluorocarbon liquids in the management of proliferative vitreoretinopathy. Am. J. Ophthalmol. 1988; 106: 668-674.
4 CHANG S., REPPUCCI V., ZIMMERMAN N.J., HEINEMANN M.H., COLEMAN D.J. Perfluorocarbon liquids in the management of traumatic retinal detachments. Ophthalmology 1989; 96: 785-792.
5 WILKINSON A.W. FARBER M.E., ZIMMERMAN N.J., - Anterior chamber toxicity for perflurotri-n-propylamine: A vitreous substitute. Invest. Ophthalmol. Vis. Sci. 1985, 25(suppl.): 34.
6 STONE W. JR. - Alloplasty in surgery of the eye. N. Engl. J. Med. 1958; 258: 486-490.
7 ARMALY M.F. - Ocular tolerance to silicones. I. Replacement of aqueous and vitreous by silicone fluids. Arch Ophthalmol. 1962; 68: 390-395.
8 LABELLE P., OKUN E. - Ocular tolerance to liquid silicone: an experimental study. Can. J. Ophthalmol. 1972, 7: 199-204.
9 LEE P., DONOVAN R.H., MUKAI N. - Intravenous injection of silicone: an experimental study. I. Clinical picture and histology of the eye. Ann. Ophthalmol. 1969; 1(2): 15-25.
10 MUKAI N., LEE P., SCHEPENS C.L. - Intravenous injection of silicone: an experimental study. II. Histochemistry and electron microscopy. Ann. Ophthalmol. 1972; 4: 273-287.
11 MUKAI N., LEE P., OGURI M., SCHEPENS C.L. - A long-term evaluation of silicone retinopathy in monkeys. Can. J. Ophthalmol. 1975; 10: 391-402.
12 MIYAMOTO K., REFOJO M.F., TOLENTINO F.I., FOURNIER G.A, ALBERT D.A. - Perfluoroether liquid as a long-term vitreous substitute: an experimental study. Retina 1984, 4: 264-268.
13 NABIH., PEYMAN G.A., CLARK L.C., Jr., HOFFMAN R.E., MICELI M., ABOUTSTEIT M., TAWAKOL M., LIU K-R. - Experimental evaluation of perfluorophenathrene as a high specific gravity vitreous substitute: A preliminary report. Ophthalmic Surg. 1989, 20: 286-293.
14 CHANG S., ZIMMERMANN. J., IWAMOTO T., ORTIZ R., FARIS D. - Experimental vitreous replacement with perfluorotributylamine. Am. J. Ophthalmol. 1987, 103: 29-37.
15 MCDONALD T.O., SHADDUCK J.A. - Eye irritation. In: Marzulli, F.N. & Maibach, H.I. (ed.): Advances in Modem Toxicology, vol. 4, pp. 139-191, 1979.
16 OBER R.R., BLANKS J.C., OGDEN T.E., PICKFORD M., MINCKLER D.S., RYAN S.J. - Experimental retinal tolerance to liquid silicone. Retina 1983; 3: 77-85.
17 MIYAMOTO K., REFOJO M.F., TOLENTINO F.I., FOURNIER G.A., ALBERT D.M. - Fluorinated oils as experimental vitreous substitutes. Arch. Ophthalmol. 1986; 104: 1053-1056.
18 CHAN C., OKUN E. - The question of ocular tolerance to intravitreal liquid silicone. A longterm analysis. Ophthalmology 1986; 93: 651-660.
Política de Privacidade. © Copyright, Todos os direitos reservados.