Freqüência da terapia de indução e reindução do ganciclovir no tratamento da retinite por citomegalovírus

Freqüência da terapia de indução e reindução do ganciclovir no tratamento da retinite por citomegalovírus


Kimble T. F. Matos,
Cristina Muccioli


Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749versão On-line ISSN 1678-2925

Arq. Bras. Oftalmol. vol.60 no.6 São Paulo dez. 1997



Cytomegalovirus (CMV) retinitis is the most common ocular infection in patients with the acquired immunodeficiency syndrome (AIDS). Ganciclovir is used to contrai the spread of CMV.


To investigate the incidence of use of induction and reinduction therapy of ganciclovir in treatment of CMV retinitis in a reference center for ocular complications of AIDS.


We evaluated retrospectively 1,100 HIV-infected patients, 407 (37%) with ocular manifestations. From the total, 246 (22.4%) patients presented CMV retinitis.


Ninety nine (40.2%) patients required an induction therapy of 10 mg/kg/day of ganciclovir for 21 days and the others 147 (59.8%) were using a maintenance therapy of 5 mg/kg/day. Thirty (1 2.2%) patients required a reinduction therapy.


The relapsed ratio of our patients was significantly lower when compared with literature 6,12. We atribule this ratio to the toxicity, spending time, and, the very inconvenient therapy.

Key-words: AIDS; Cytomegalovirus; Retinitis; Ganciclovir; Intraocular inflammation


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