Freqüência da terapia de indução e reindução do ganciclovir no tratamento da retinite por citomegalovírus

Freqüência da terapia de indução e reindução do ganciclovir no tratamento da retinite por citomegalovírus

Autores:

Kimble T. F. Matos,
Cristina Muccioli

ARTIGO ORIGINAL

Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749versão On-line ISSN 1678-2925

Arq. Bras. Oftalmol. vol.60 no.6 São Paulo dez. 1997

http://dx.doi.org/10.5935/0004-2749.19970004

SUMMARY

Background:

Cytomegalovirus (CMV) retinitis is the most common ocular infection in patients with the acquired immunodeficiency syndrome (AIDS). Ganciclovir is used to contrai the spread of CMV.

Purpose:

To investigate the incidence of use of induction and reinduction therapy of ganciclovir in treatment of CMV retinitis in a reference center for ocular complications of AIDS.

Methods:

We evaluated retrospectively 1,100 HIV-infected patients, 407 (37%) with ocular manifestations. From the total, 246 (22.4%) patients presented CMV retinitis.

Results:

Ninety nine (40.2%) patients required an induction therapy of 10 mg/kg/day of ganciclovir for 21 days and the others 147 (59.8%) were using a maintenance therapy of 5 mg/kg/day. Thirty (1 2.2%) patients required a reinduction therapy.

Conclusions:

The relapsed ratio of our patients was significantly lower when compared with literature 6,12. We atribule this ratio to the toxicity, spending time, and, the very inconvenient therapy.

Key-words: AIDS; Cytomegalovirus; Retinitis; Ganciclovir; Intraocular inflammation

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