Hipotireoidismo e glaucoma: investigação de uma possível associação

Hipotireoidismo e glaucoma: investigação de uma possível associação


Vital P. Costa,
Ricardo Suzuki,
Ana Paula A. C. Costa,
Michel Honda,
Robert Ritch,
Meyer Knobel,
Geraldo Medeiros-Neto


Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749versão On-line ISSN 1678-2925

Arq. Bras. Oftalmol. vol.61 no.1 São Paulo fev. 1998



To investigate the association between primary open-angle glaucoma (POAG) and hypothyroidism.


In the first study, 15 patients with hypothyroidism were analyzed to verify the presence of POAG. In the second study, a TSH assay was employed as a screening test to determine the incidence of hypothyroidism in 65 patients with POAG.


None of the 15 patients with hypothyroidism had clinical findings compatible with POAG, and the mean intraocular pressure measurements were 15.8 ± 2.3 mmHg (range 11 to 21 mmHg). Only one (1.5%) of the 65 POAG patients showed abnormal TSH levels, and was diagnosed as having subclinical hypothyroidsm.


These findings do not support the existence of a positive correlation between hypothyroidism and POAG.

Key words: Glaucoma; Hypothyroidism; Thyroid; Intraocular Pressure


1 Greenspan FS, Baxter JD. Basic & Clinical Endocrinology. 4th ed. Appleton & Lange, Connecticut, USA, 1994, pp.l71-190.
2 Hertel G. Einiges über den Augendruck und Glaukom. Klin Monatsbl Augenheilkd 1920;64:390-392.
3 Ritch R, Podos SM. Hypothyroidism and glaucoma (letter). Ophthalmology 1994;101:623-4.
4 Smith KD, Tevaarwerk GJM, Allen LH. Reversal of poorly controlled glaucoma upon diagnosis and treatment of hypothytoidism. Can J Ophthalmol 1992;27:345-7.
5 Smith KD, Tevaarwerk GJM, Allen LH. An ocular dynamic study supporting the hypothesis that hypothyroidism is a treatable cause of secondary open angle glaucoma. Can J Ophthalmol 1992;27:341-4.
6 Pestereva AA. Early diagnosis, treatment and prevention of disorders of intraocular pressure and hydrodynamics in patients with hypothyroidism in the Carpathian region. Ophthalmol Zh 1988;4:215-8.
7 Mclenachan J, Davies DM. Glaucoma and the Thyroid. Br J Ophthalmol 1965;49:441-4.
8 Smith KD, Arthurs BP, Saheb N. An association between hypothyroidism and primary open-angle glaucoma. Ophthalmology 1993; 100:1580-4.
9 Stein R, Romano A, Treister G, Bartov E. Effect of subconjunctival injection of hyaluronidase on outflow resistance in normal and in open-angle glaucomatous patients. Metab Pediatr Syst Ophthalmol 1982;6:169-74.
10 Góes-Monteiro R. Contribuição ao estudo da pressão intra-ocular normal em brasileiros. Rev Bras Oftalmol 1972;31 :317-25.
11 Goldmann H, Schmidt T. Üeber Applanationstonometrie. Ophthalmologica 1956;134:221-42.
12 Cheng H, Perkins ES. Thyroid disease and glaucoma. Br J Ophthalmol 1967;51:547-53.
13 Krupin T, Jacobs LS, Podos SM, Becker B. Thyroid function and the intraocular pressure response to topical corticosteroids. Am J Ophthalmol 1977;83:643-6.
14 Cartwright MJ, Grajewski AL, Friedberg ML, Anderson DR Richards DW. Immune-related disease and normal-tension glaucoma: A case control study. Arch. Ophthalmol 1992;110:500-2.
15 Jämsen, K. - Thyroid disease, a risk factor for optic neuropathy mimicking normal-tension glaucoma. Acta Ophthalmol Scand 1996;74:456-60.