Imunidade celular ao antígeno S em pacientes com uveíte endógena

Imunidade celular ao antígeno S em pacientes com uveíte endógena


J. H. Yamamoto,
C. E. Hirata,
C. R. Gonçalves,
Y. Fujino,
E. Olivalves,
J. Kalil


Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749versão On-line ISSN 1678-2925

Arq. Bras. Oftalmol. vol.60 no.6 São Paulo dez. 1997


Experimental and clinicai studies on S-antigen (SAg) and other retinal specific antigens have demonstrated their importance not only in the pathogenesis of various endogenous uveitis but also in the elaboration of new forms of immunotherapy. The present study aims to analyze the profile of in vitro cellular immunity to bovine SAg and to two of its immunodominant peptides, peptide M and peptide G, in Brazilian patients with Behçet's disease (BD) with uveitis, Vogt-Koyan agi Harada 's disease (VKH), retinal vasculitis, BD without uveitis and in a contral group. The frequency of positive responses to SAg was 42%, 52%, RO%, 4 7% a n d 25% in patients with BD with uveitis, VKH, retinal vasculitis, BD without uveitis and in the contral group, respectively. The Fequency of positive responses to peptide M was 26%, 60%, 6% a n d 6%, respectively, and, top eptide G was 21 %, 30%, 80%, 6% a n d 6%, respectively. Although there was no statistically significant difference amongth e groups analyzed, the present study demons trated the importance of AgS in patients with endogenous uveitis. Patients with BD without uveitis recognized the whole molecule but not the peptides suggesting that there are different responses to diverse AgS epitopes making possible some speculation about the mechanisms of uveitis induction.


1 GERY, I., MOCHIZUKI, M.; NUSSENBLATT, R. B. - Retinal specific antigens and immunopathogenic processes they provoke. In: Progress in retinal research, Osborne N, Chader GJ, eds. Oxford: Pergamon Press. 1986: 75 - 109.
2 NUSSENBLATT, R. B.; KUWABARA, T.; DEMONASTERIO, F. M.; WACKER, W. B. - S-antigen uveitis in primates. Arch. Ophthalmol., 99: 1090-1092, 1981.
3 CASPI, R.; ROBERGE, F. G.; MACALLISTER, C. G.; EL-SAIED, M.; KUWABARA, T.; GERY, I.; HANNA, E.; NUSSENBLATT, R. B. - T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat. J. Immunol., 136: 928 -933, 1986.
4 NUSSENBLATT, R. B., GERY, I., BALLINTINE, E. J. - Cellular immune responsiveness of uveitis patients to retinal S-antigen. Am. J. Ophthalmol., 89: 173-179, 1980.
5 DE SMET, M. D.; YAMAMOTO, J. H.; MOCHIZUKI, M.; GERY, I., SINGH, V. K., SHINOHARA, T., WIGGERT, B.; CHADER, G. J.; NUSSENBLATT, R. B. - Cellular immune responses of patients with uveitis to retinal antigens and their fragments. Am. J. Ophthalmol., 110: 135 - 142, 1990.
6 DOREY, C.; COZETTE, J.; FAURE, F. P. - A simple and rapid method for isolation of retinal Santigen. Ophthalmic Res., 14: 249-255, 1982.
7 YAMAKI, K.: TSUDA, M.; SHINOHARA, T. - The sequence of human retinal S-antigen reveals similarities with 𝑎-transducin. FEB., 234, 39-43, 1988.
8 DONOSO, L. A.; YAMAKI, K.; MERRYMAN, C. F.; SHINOHARA. T., YUE, S., SERY, T. W. - Human S-antigen: characterization of uveitopathogenic sites. Curr. Eye Res., 7: 1077-85, 1988.
9 GREGERSON, D. S.; MERRYMAN, C. M., OBRITSCH, W. F.; DONOSO, L. A. - Identification of a potent new pathogenic site in human retinal S-antigen which induces experimental auto immune uveoretinitis in LEW rats. Cell. Immunol., 128: 209-19, 1990.
10 YAMAMOTO, J. H.. MINAMI, M.; INABA, G.; MASUDA. G.; MOCHIZUKI, M. - Cellular auto immunity to retinal specific antigens in patients with Behçet's disease. Br. J. Ophthalmol., 77: 584-9, 1993.
11 DE SMET, M. D.; WIGGERT, B.; CHADER, G. J.; MOCHIZUKI, M.; GERY, I.; NUSSENBLATT, R. B. - Cellular immune responses to fragments of S-antigen in patients with uveitis. Ocular Immunology Today,. 285 - 288. 1990.
Política de Privacidade © Copyright, Todos os direitos reservados.