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Norfloxacino a 0,3% no tratamento de conjuntivites e blefaroconjuntivites agudas

Norfloxacino a 0,3% no tratamento de conjuntivites e blefaroconjuntivites agudas

Autores:

Milton Ruiz Alves,
Fernando Oréfice,
Paiva Gonçalves Neto,
Marciano Filgueira da Vila

ARTIGO ORIGINAL

Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749versão On-line ISSN 1678-2925

Arq. Bras. Oftalmol. vol.54 no.5 São Paulo set./out. 1991

http://dx.doi.org/10.5935/0004-2749.19910011

SUMMARY

Tolerability and efficacy of norfloxacin 0,3% ophthalmic solution were evaluated in 103 patients with acute conjunctivitis or blepharoconjunctivitis of presumed bacterial etiology. Symptoms improved clearly 24 to 48 hours after starting therapy. In 91,3% of patients no adverse reaction was detected. The most frequent causative agents were S. epidermidis and S. aureus, and the in vitro sensibility of these bacteria to norfloxacin was respectively 91,2% and 91,3%. These results confirm the potencial shown in in vitro studies for the use of norfloxacin in the treatment of superficial infections of the eye and adnexae.

Key words: Conjunctivitis; blepharoconjunctivitis; quinolones; norfloxacin; susceptibilitytest

REFERÊNCIAS

1 COSTER D.J. Bacterial conjunctivitis. In Fraunfelder F.T. & Roy F.H. (ed). Current Ocular Therapy 3. Philadelphia, Saunders Co., 1990. p.402-3.
2 FRAUNFELDER F.T., BAGBY G.C., KELLY D.J. Fatal aplastic anemia following topical administration of ophthalmic chloramphenicol. Am. J. Ophthalmol., 93: 356-60, 1982.
3 GICLIOTTI F., HENDLEY J.O., MORGAN J. Efficacy of topical antibiotic therapy in acute conjunctivitis in children. J. Pediatr., 104: 623-6,1984.
4 GOLDSTEIN J.G., DIANE M.C., BENDON L. et al. Potential of topical Norfloxacin therapy. Comparative in vitro activity against clinical ocular bacterial isolates. Arch. Ophthalmol., 105: 991-4, 1987.
5 JARUDI N., GOLDEN B., HOYME J. et al. Comparison of antibiotic therapy in presumptive bacterial conjunctivitis. Am. J. Ophthalmol., 79: 790-4,1975.
6 LEIBOWITZ H.M., PRATI M.V.; FLAGSTAD I.J., et al. Human Conjunctivitis. T - Diagnostic Evaluation. Arch. Ophthalmol., 94: 1747-9, 1976.
7 LOCATCHER-CHORAZO D. & SEEGAR B.C. Microbiology of the eye: the bacterial flora of the healthy eye. St. Louis, The C.V. Mosby Co., 1972. p.13-5
8 MOLINARI H., BELFORT JR.R., ALMEIDA A.T., SILVA V.L.P. Análise clínico-laboratorial de 247 pacientes portadores de conjuntivite, úlcera de córnea e endoftalmite. Rev. Bras. Oftal., 37: 63-73, 1978.
9 SHUNGU D.L.,TUTLANE V.K.,WEINGERG E., GADEBUSCH A.H. In vitro antibacterial activity of norfloxacin, another agent against ocular pathogens, Chemotherapy 31: 112-8, 1985.
10 WILHELMUS K.R., GILBERT M.L., OSATO M.S. Tobramycin in Ophthalmology. Suv. Ophthalmol. 32: 111-22, 1987.
11 Dados de arquivo dos Laboratórios de Pesquisa de MERCK SHARP & DOHME. In: Monografia - Chibroxin. Uma nova solução oftálmica antibacteriana de amplo espectro, membro das fluoroquinolonas. 1989.