Retinoblastoma: análise cromossômica

Retinoblastoma: análise cromossômica


Clélia Maria Erwenne,
Maria Cecília Menks Ribeiro,
Raquel Joffe,
Joyce A. D. Andrade,
José Carlos Gouvêa Pacheco


Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749versão On-line ISSN 1678-2925

Arq. Bras. Oftalmol. vol.53 no.4 São Paulo jul./ago. 1990


The article refers to the karyotype analysis of 27 unilateral or bilateral retinoblastoma patients from both sexes, sporadic or familial, before sistemic chemotherapy or at least 6 months after it, selected at A.C. Camargo Hospital/Antonio Prudente Foundation - São Paulo. Patients with congenital malformations, phenotypic alterations or mental retar dation were the priority for this examination. Inespecific chromoso mopathy was founded in 2 patients who were exposed to multiple che motherapy. In other 3 known alte rations were seem (47,XX+G; 46,XY/47,XY+G; 46,XY/46XY, 13q-). The authors discussed these asso ciations and the indications of karyotype analysis in retinoblastoma patients.


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