Uso tópico pós-operatório versus aplicação intra-operatória da mitomicina C a 0,02%, na prevenção de recidivas pós-operatórias do pterígio primário

Uso tópico pós-operatório versus aplicação intra-operatória da mitomicina C a 0,02%, na prevenção de recidivas pós-operatórias do pterígio primário


José Augusto Cardillo,
Milton Ruiz Alves,
Newton Kara José,
Alfredo Tranjan Neto,
Juliana Fonseca Serpa,
Luciano Eneas Ambrósio


Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749versão On-line ISSN 1678-2925

Arq. Bras. Oftalmol. vol.58 no.6 São Paulo dez. 1995



This study was carried out to determine the efficacy of the intraoperative application of subconjunctival O. 02% mitomycin C and topical O. 02% mitomycin C instilled postoperatively, on pterygium recurrence after surgical excision.

Methods and results:

45 eyes of 45 patients were treated with the intraoperative application of mitomycin C and three cases showed pterygium recurrence (6.67%). A cell sponge was soaked with a 0.02% solution of mitomycin C and placed in contact with the exposed scleral bed for 3 minutes. 47 eyes of 47 patients after pterygium excision received 0.02% mitomycin C eyedrops 3 times a day for 5 days and two cases showed recurrence (4.26%). Follow up time for ali cases exceeded eighteen months.


The comparison between the efficacy of the intraoperative application versus topical use of the drug didn't show significant difference.


1 CHEN, C-W. - Enhanced intraocular pressure controlling effectiveness of trabeculectomy by local application of mitomycin-C. Trans. Asia-Pacific Acad. Ophthalmol., 9: 172-7, 1983.
2 PALMER, S. S. - Mitomycin as adjunt chemotherapy with trabeculectomy. Ophthalmology, 98: 317-21, 1991.
3 YAMAMOTO, T.; VARANI, J.; SOONG, H. K.; LICHTER, P. R. - Effects of 5-fluorouracil and mitomycin C on cultured rabbit subconjunctival fibroblasts. Ophthalmology 97: 1204-10, 1990.
4 JAMPEL, H. D. - Effect of brief exposure to mitomycin C on viability and proliferation of cultured human Tenon's capsule fibroblasts. Ophthalmology, 99: 1471-6, 1992.
5 KHAW, P. T.; DOYLE, J. W.; SHERWOOD, M. B.; GRIERSON, I.; SHULTZ, G.; McGORRAY, S. - Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin C Arch. Ophthalmol., 111: 263-7, 1993.
6 FRUCHT-PERY, J.; lLSAR, M.; HEMO, I. - Single dosage of mitomycin C for prevention of recurrent pterygium. Preliminary report. Cornea, 13: 411-3, 1994.
7 CARDILLO, J. A.; ALVES, M. R.; KARA JOSÉ, N.; CAMARGO, J. F. C.; SERPA, J. F.; AMBROSIO, L. E.; MOREIRA FILHO, D. C.; Eficácia da mitomicina C a 0,04% na prevenção de recidivas do pterígio primário: aplicação intraoperatória versus uso tópico pós-operatório. Rev. Bras. Oftal., em publicação.
8 YAMANOUCHI, U. - Scleral changes induced by instillation of mitomycin C. Acta Med. Nagasaki, 28: 99-110, 1983.
9 RUBINFELD, R. S.; PHISTER, R. R.; STEIN, R. M.; FOSTER, S.; MARTIN, N. F.; STOLERU, S.; TALLEY, A. R.; SPEAKER, M. G. - Serious complications of topical mitomycin C after pterygium surgery. Ophthalmology, 99: 1647-54, 1992.
10 KEARNS, L. A. - Mitomycin C use is linked to corneal melt. Ocular Surgery News, 11: 15, 1994.
11 ORAM, O.; GROSS, R. L.; WILHELMUS, K. R.; HOOVER, J. A. - Necrotizing keratitis following trabeculectomy with mitomycin. C Arch. Ophthalmol., 113: 19, 1995.
12 SUGAR, A. - Who should receive mitomycin C after pterygium surgery? Ophthalmology, 99: 1645-6, 1992.
13 JABBUR, N. S.; BLAIR, S. D.; RUBIENFELD, R. S.; ZIESKE, J. D.; FOSTER, C. S. - The effect of mitomycin C on corneal limbal stem cells. Invest. Ophthalmol. Vis. Sci., (suppl.) 35: 1977, 1994.